Research Article
Cilengitide Inhibits Neovascularization in a Rabbit Abdominal Aortic Plaque Model by Impairing the VEGF Signaling
Figure 7
Cilengitide inhibits the VEGF expression in rabbit abdominal aortic plaque. (a, b) The representative image and quantification of VEGF-A in the plaque of the abdominal aorta. (c) The mRNA expression of VEGF in the plaque of the abdominal aorta. (d, e) The content of VEGF-A and VEGF-R2 was evaluated by ELISA in the plaque of the abdominal aorta. (f–h) Relative mRNA of αv, β3, and β5 in the plaque of the abdominal aorta. (i–l) The representative image and quantification of MMP-2, MMP-9, and MCP-1 expression in the plaque of the abdominal aorta. for the control, T0, and T1 groups; for the T2 group. vs. the control group; vs. the T0 group; vs. the T0 group.
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