An Update on Assessment, Therapeutic Management, and Patents on Insomnia

Table 5

Patents granted/published for various dosage forms for treatment of Insomnia.

Patent no.	Country of filing	Composition/active ingredient	Major outcome	Publication/grant year	Ref.
8926991	USA	Botulinum toxin	For treating primary disorders of mood and affect with a neurotoxin, including depression, nervousness, and sleep disorders.	2015	[191]
US 8252809B2	USA	Zolpidem	Solid dosage form for treating midnight insomnia by administration of low doses (5 mg or less) of zolpidem or a salt thereof.	2012	[192]
US 8242131B2	USA	Zolpidem	Methods and compositions for treatment of midnight insomnia by administration of low doses (5 mg or less) of zolpidem or a salt thereof.	2012	[193]
US 8148393B2	USA	Zolpidem	A modified release zolpidem tablet is designed as a tablet-in-tablet dosage form.	2012	[194]
US 8034371 B2	USA	Zolpidem	Intranasal solutions of zolpidem for the prevention/treatment of insomnia or the therapy of neurological diseases.	2011	[195]
US 7914826	USA	Combination containing melatonin and other herbal supplements	Supplemental compositions and methods for inducing a restful night’s sleep by rapidly inducing a person to fall asleep and to maintain sleep.	2011	[196]
US 7906154	USA	Combination containing melatonin and other herbal supplements	Supplemental compositions and methods for inducing a restful night’s sleep by rapidly inducing a person to fall asleep and to maintain sleep.	2011	[197]
US 7655681B2	USA	Zonisamide	For treatment or prevention of obstructive sleep apnea (OSA) by the administration of a pharmacologically effective amount of zonisamide to a patient	2010	[198]
US 7632517B2	USA	Zolpidem	Zolpidem containing buccal aerosol sprays or capsules for faster absorption through the oral mucosa, leading to faster onset of effect for insomnia.	2009	[199]
US 6998112B2	USA	Sleep-inducing natural herb or hormone	A toothpaste for inducing sleep while simultaneously promoting intraoral cleanliness, which includes toothpaste base ingredients and at least one sleep-inducing natural herb or hormone and these are selected from the group consisting of chamomile, lemon balm, passion flower, and valerian, and the hormone melatonin.	2006	[200]
US 6703412 B1	USA	Melatonin	A method of treating sleeplessness in humans by administering an effective sleep-inducing amount of not greater than about 5 mg of melatonin	2004	[201]