3D-QSAR-Based Pharmacophore Modeling, Virtual Screening, and Molecular Docking Studies for Identification of Tubulin Inhibitors with Potential Anticancer Activity

Figure 6

Pictorial representation of the contour maps generated in the context of (c, d) hydrogen bond donor, (e, f) hydrophobic features, and (g, h) electron-withdrawing groups with (a) most active compound 22 and (b) least active compound 62 using the QSAR model.

(a)

(b)

(c)

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(h)