Serum TNF-α Level as a Possible Predictor of Inhibitor Levels in Severe Hemophilia A

Table 1

Subjects’ characteristics.

No.	Characteristics	Inhibitor FVIII (BU/mL)
		Low titer ()	High titer ()
1.	Age (years old)
	Mean	10.31	11.66
	SD	6.91	7.66
	Range	1-31	1-35
2.	Father’s ethnicity
	Sunda	33 (36.7%)	36 (40%)
	Jawa	10 (11.1%)	7 (7.8)
	Minang	1 (1.1%)	1 (1.1)
	Aceh	1 (1.1%)	0
	Batak	0	1 (1.1%)
3.	Mother’s ethnicity
	Sunda	40 (44.5%)	41 (45.6%)
	Jawa	4 (4.4%)	3 (3.3%)
	Minang	1 (1.1%)	0
	Batak	0	1 (1.1%)
4.	Blood group
	A	19 (21.1%)	13 (14.4%)
	B	13 (14.4%)	9 (10.0%)
	AB	0	6 (6.8%)
	O	13 (14.4%)	17 (18.9%)
5.	Bleeding manifestations location (joint-nonjoint)
	Joint (hemarthrosis)	31 (34.5%)	33 (36.7%)
	Muscle (hematoma)	2 (2.2%)	5 (5.5%)
	Joint and muscle	11 (12.2%)	7 (7.8%)
	Intracranial hemorrhage	1 (1.1%)	0
6.	Bleeding episode
	<2 times/month	10 (11.1%)	8 (8.9%)
	≥2 times/month	35 (38.9%)	37 (41.1%)
7.	Age of the start of therapy
	<12 months old	6 (6.7%)	8 (8.9%)
	≥12 months old	39 (43.3%)	37 (41.1%)
8.	FVIII replacement therapy
	Plasma-derived	26 (28.9%)	32 (35.6%)
	Mixed (recombinant/cryocypitate)	19 (21.1%)	13 (14.4%)
9.	Frequency FVIII replacement therapy
	<2 times/month	11 (12.2%)	11 (12.2%)
	≥2 times/month	34 (37.8%)	34 (37.8%)
10.	Family history with hemophilia
	Exist	29 (32.2%)	26 (28.9%)
	None	16 (17.8%)	19 (21.1%)

value for all variable was > 0.05.