Derangement of Liver Enzymes, Hyperglycemia, Anemia, and Associated Factors among HIV-Infected Patients Treated with Tenofovir Disoproxil Fumarate-Based Regimen in Ethiopia: A Prospective Cohort Study

Table 3

Univariate binary logistic regression analysis of variables associated with elevated liver enzymes.

Variables	Category	Elevated liver enzymes
		ALT; COR (95% CI)	AST; COR (95% CI)	ALP; COR (95% CI)
Sex	Female	0.93 (0.08, 10.86)	NA	3.71 (0.94, 14.6)
Age	>40 years	1 (0.09, 11.7)	4.32 (0.37, 50.58)	2.11 (0.7, 6.38)
BMI	>25 kg/m^2	4.32 (0.37, 50.58)	4.32 (0.37, 50.58)	1.54 (0.51, 4.65)
CD4	<200 cells/mm^3	0.57 (0.05, 6.65)	0.57 (0.05, 6.65)	2.29 (0.78, 6.78)
Cart	TDF+3TC + ATV/r	NA	NA	0.84 (0.15, 4.78)
Cotrimoxazole	Yes	NA	1 (0.09, 11.7)	0.9 (0.29, 2.74)
Isoniazid	Yes	3.79 (0.3, 47.36)	3.79 (0.3, 47.36)	2.44 (0.54, 10.96)
PPI	Yes	3.25 (0.26, 40.12)	3.25 (0.26, 40.12)	1.09 (0.24, 4.88)
Prior ART	Yes	NA	NA	1.48 (0.23, 9.65)
OPIs	Yes	NA	NA	1.34 (0.29, 6.27)
Diabetes	Yes	NA	NA	2.21 (0.13, 37.25)
Hypertension	Yes	NA	NA	0.72 (0.07, 7.2)
Cancer	Yes	NA	NA	1.34 (0.29, 6.27)

BMI: body mass index; CD4: cluster of differentiation; cART: combination of antiretroviral therapy; PPI: proton pump inhibitor; OPIs: opportunistic infections; NA: not applicable. stands for variables with value of < 0.25.