Research Article

Prediction of a Potential Mechanism of Intervertebral Disc Degeneration Based on a Novel Competitive Endogenous RNA Network

Table 5

Gene ontology enrichment analysis of 80 DEGs and 49 genes that formed the miRNA–mRNA interaction relationship.

Sample groupCategoryTermCount valueGenes

80CCExtracellular exosome250.000123351GALNT3; LPL; HYAL1; ACTC1; HIST1H2AE; QDPR; SELENBP1; NPR3; TMEM27; EMILIN1; LYVE1; KRT19; TEX14; PTGDS; VAMP8; DMKN; AOX1; GDF15; CFD; SPON2; NQO1; DEFB1; IGFBP3; DCXR; HIST1H4H
80CCExtracellular space160.000207983IBSP; HYAL1; LPL; ACTC1; CYTL1; SELENBP1; PTHLH; TNFAIP6; PTGDS; SCGB1D2; TFPI; SPON2; CFD; GDF15; IGFBP3; DEFB1
49MFVirus receptor activity40.00065HYAL1; LDLR; CD80; EFNB2
80BPCellular response to zinc ion30.002491898MT1M; MT1G; MT1F
80BPNegative regulation of growth30.002491898MT1M; MT1G; MT1F
80MFVirus receptor activity40.002592014HYAL1; LDLR; CD80; EFNB2
80CCExtracellular region150.003781513IBSP; LPL; EMILIN1; PTHLH; PTGDS; NPTX2; DMKN; TFPI; TREM1; CFD; GDF15; IGFBP3; DEFB1; HIST1H4H; COL10A1
80BPViral entry into host cell40.003840079LDLR; CD80; VAMP8; EFNB2
80BPCell adhesion70.009200697IBSP; TNFAIP6; LYVE1; CYP1B1; EFNB2; SPON2; EMILIN1
49MFHyaluronan synthase activity20.009680585HYAL1; HAS2
80MFHyaluronan synthase activity20.015548781HYAL1; HAS2
49BPViral entry into host cell30.017061685LDLR; CD80; EFNB2
49BPHyaluronan biosynthetic process20.017380591HYAL1; HAS2
80BPCell-cell signaling50.017725805PTHLH; TNFAIP6; CD80; EFNB2; GDF15
80THNeral absorption30.019704118MT1M; MT1G; MT1F
49MFTranscriptional activator activity, RNA polymerase II transcription regulatory region sequence spec30.022287725LMO2; GATA6; FOXF2
80BPResponse to estrogen30.026997667KRT19; CCND1; GATA6
80BPHyaluronan biosynthetic process20.027195604HYAL1; HAS2
49BPCell adhesion50.027213497IBSP; LYVE1; CYP1B1; EFNB2; SPON2
80MFTranscription factor activity, RNA polymerase II distal enhancer sequence-specific binding30.027502988T; GATA6; FOXF2
49BPResponse to ethanol30.028347603ACTC1; CCND1; NQO1
49BPRetinal metabolic process20.029614391CYP1B1; SDR16C5
49MFTranscription factor binding40.031391824HYAL1; CCND1; GATA6; FOXF2
80BPCellular response to interleukin-130.031774689HYAL1; TFPI; HAS2
49BPPositive regulation of urine volume20.032043246HAS2; NPR3
49BPNitric oxide biosynthetic process20.032043246CYP1B1; NQO1
49BPPositive regulation of angiogenesis30.033505165HYAL1; CYP1B1; GATA6
49BPPositive regulation of transcription from RNA polymerase II promoter70.033985253DLX3; LMO2; GATA6; EBF1; FOXF2; CYTL1; ZEB2
49BPHyaluronan catabolic process20.036883166HYAL1; LYVE1
49BPResponse to drug40.040149506LPL; ACTC1; CCND1; GATA6
80CCTranscription factor complex40.040958701LMO2; GATA6; FOXF2; PDLIM1
80BPExtracellular matrix organization40.041931952IBSP; FOXF2; EMILIN1; COL10A1
49BPCellular response to platelet-derived growth factor stimulus20.044098781HYAL1; HAS2
80BPRetinal metabolic process20.046173764CYP1B1; SDR16C5
80BPResponse to estradiol30.049819454CCND1; TFPI; NQO1
80BPNitric oxide biosynthetic process20.049925405CYP1B1; NQO1
80BPPositive regulation of urine volume20.049925405HAS2; NPR3

MF: molecular function; BP: biological process; CC: cellular component.