Overexpression of Long Noncoding RNA H19 Downregulates miR-140-5p and Activates PI3K/AKT Signaling Pathway to Promote Invasion, Migration and Epithelial-Mesenchymal Transition of Ovarian Cancer Cells

<div>H19 overexpression activated the PI3K/AKT/mTOR pathway and the downstream protein expression in Anglne cells. (a, b) Western blot analysis of the PI3K/AKT/mTOR signaling pathway-related proteins in Anglne cells after tranfection. (c, d) Expression of the downstream proteins Forkhead box protein O1 (FoxO1), p-FoxO1 (Ser256), Murine Double Mimute 2 (MDM2), p-MDM2 (Ser166), NF-<i>κ</i>B p65, and p-NF-<i>κ</i>B p65 (Ser536) in Anglne cells after transfection was detected by western blot. 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BioMed Research International

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Figure 5

Figure 5: Overexpression of Long Noncoding RNA H19 Downregulates miR-140-5p and Activates PI3K/AKT Signaling Pathway to Promote Invasion, Migration and Epithelial-Mesenchymal Transition of Ovarian Cancer Cells 

Figure 5 | Overexpression of Long Noncoding RNA H19 Downregulates miR-140-5p and Activates PI3K/AKT Signaling Pathway to Promote Invasion, Migration and Epithelial-Mesenchymal Transition of Ovarian Cancer Cells 