Research Article

Network Pharmacology and Molecular Docking-Based Prediction of the Mechanism of Qianghuo Shengshi Decoction against Rheumatoid Arthritis

Table 1

Information of 87 potential targets.

No.Target nameGene nameGene ID

T1Prostaglandin G/H synthase 2PTGS25743
T2Estrogen receptorESR12099
T3Heat shock protein HSP 90-betaHSP90AB13326
T4Androgen receptorAR367
T5Nitric oxide synthase, inducibleNOS24843
T6Serine/threonine-protein kinase pim-1PIM15292
T7Cyclin-dependent kinase 2CDK21017
T8Peroxisome proliferator-activated receptor gammaPPARG5468
T9Glycogen synthase kinase-3 betaGSK3B2932
T10Prostaglandin G/H synthase 1PTGS15742
T11Cyclin-A2CCNA2890
T12Mitogen-activated protein kinase 14MAPK141432
T13Serine/threonine-protein kinase Chk1CHEK11111
T14cAMP-dependent protein kinase catalytic subunit alphaPRKACA5566
T15AcetylcholinesteraseACHE43
T16DNA topoisomerase 2-alphaTOP2A7153
T17Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoformPIK3CG5294
T18Vascular endothelial growth factor receptor 2KDR3791
T19Nitric oxide synthase, endothelialNOS34846
T20Amine oxidaseMAOB4129
T21Carbonic anhydrase 2CA2760
T22Apoptosis regulator Bcl-2BCL2596
T23Transcription factor AP-1JUN3725
T24DNA topoisomerase 2-betaTOP2B7155
T25Interstitial collagenaseMMP14312
T26Tumor necrosis factorTNF7124
T27Xanthine dehydrogenase/oxidaseXDH7498
T28Glutathione S-transferase PGSTP12950
T29Mitogen-activated protein kinase 1MAPK15594
T30Cellular tumor antigen p53TP537157
T31Interleukin-6IL63569
T32Glucocorticoid receptorNR3C12908
T33Heme oxygenase 1HMOX13162
T34Insulin receptorINSR3643
T35Retinoblastoma-associated proteinRB15925
T36Superoxide dismutaseSOD16647
T37Serum paraoxonase/arylesterase 1PON15444
T38C-C motif chemokine 2CCL26347
T39Cyclin-dependent kinase 1CDK1983
T40Cytochrome P450 3A4CYP3A41576
T41Cytochrome P450 1A2CYP1A21544
T42E-selectinSELE6401
T43Vascular cell adhesion protein 1VCAM17412
T44Arachidonate 5-lipoxygenaseALOX5240
T45Aryl hydrocarbon receptorAHR196
T46Glutathione S-transferase Mu 1GSTM12944
T47Glutathione S-transferase Mu 2GSTM22946
T48Urokinase-type plasminogen activatorPLAU5328
T49Epidermal growth factor receptorEGFR1956
T50Vascular endothelial growth factor AVEGFA7422
T5172 kDa type IV collagenaseMMP24313
T52Cyclin-dependent kinase 4CDK41019
T53DNA topoisomerase 1TOP17150
T54Interleukin-2IL23558
T55Interferon gammaIFNG3458
T56Peroxisome proliferator-activated receptor deltaPPARD5467
T57Mitogen-activated protein kinase 8MAPK85599
T58Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoformPPP3CA5530
T59Aldo-keto reductase family 1 member C3AKR1C38644
T60Amine oxidaseMAOA4128
T61Amyloid-beta precursor proteinAPP351
T62Caspase-7CASP7840
T63Hepatocyte growth factor receptorMET4233
T64Stromelysin-1MMP34314
T65Pro-epidermal growth factorEGF1950
T66NADPH--cytochrome P450 reductasePOR5447
T67Ornithine decarboxylaseODC14953
T68Endoplasmic reticulum chaperone BiPHSPA53309
T69Acetyl-CoA carboxylase 1ACACA31
T70Tissue factorF32152
T71Gap junction alpha-1 proteinGJA12697
T72Interleukin-1 betaIL1B3553
T73Tissue-type plasminogen activatorPLAT5327
T74ThrombomodulinTHBD7056
T75Collagen alpha-1COL1A11277
T76MyeloperoxidaseMPO4353
T77Collagen alpha-1COL3A11281
T78Cathepsin DCTSD1509
T79Mitogen-activated protein kinase 3MAPK35595
T80Fatty acid synthaseFASN2194
T81Low-density lipoprotein receptorLDLR3949
T82CatalaseCAT847
T83AromataseCYP19A11588
T84Glutathione reductase, mitochondrialGSR2936
T85Multidrug resistance-associated protein 1ABCC14363
T86Aldo-keto reductase family 1 member C1AKR1C11645
T87Aspartate aminotransferase, cytoplasmicGOT12805