Downregulation of miR-497-5p Improves Sepsis-Induced Acute Lung Injury by Targeting IL2RB

Figure 1

Bioinformatics predicted miR-497-5p and the target gene IL2RB. Volcano plots of DEMs (a) and heat map (b) analysis miRNA expressions in sepsis or corresponding normal samples from GEO database. Volcano plots of DEGs (c) and heat map (d) analysis mRNA expressions in sepsis or corresponding normal samples from GEO database. Volcano plot red dots: significantly highly expressed genes; green dots: significantly poorly expressed genes. Heat map red: significantly highly expressed genes; green: significantly poorly expressed genes. (e) The miRNA-target regulatory network. Triangles and circles represented miRNAs and target genes, respectively. Red represented genes that were upregulated, and green represented genes that were downregulated.

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