Downregulation of miR-497-5p Improves Sepsis-Induced Acute Lung Injury by Targeting IL2RB

Figure 7

Downregulation of miR-497-5p improved ALI induced by sepsis. The septic mice with ALI were established by stimulating mice with LPS. The lung tissues of sacrificed mice were obtained. (a) qRT-PCR for miR-497-5p pulmonary expression. (b) H&E was used to stain sectioned lung tissue samples and lung injury scoring for the degree of lung injury. (c) H&E histological images (400x magnification). (d) Western blot for apoptosis-related protein expression. (e) qRT-PCR for mRNA levels of TNF-α, IL-1β, and IL-6.

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