Donor Preconditioning with Inhaled Sevoflurane Mitigates the Effects of Ischemia-Reperfusion Injury in a Swine Model of Lung Transplantation

Figure 1

Experimental design. In the IRI group, the left lung was preserved in a semi-inflated state at 4°C for 24 hours and then implanted in the animal recipients, which were then observed and monitored for 6 hours. In the IRI+SEV group, animal donors received pretreatment with SEV for 30 min prior to cross-clamp and perfusion. Then, the graft was preserved in a semi-inflated state at 4°C for 24 hours and implanted in the animal recipients, which were then observed and monitored for 6 hours. SEV: sevoflurane; IRI: ischemia-reperfusion injury.