Donor Preconditioning with Inhaled Sevoflurane Mitigates the Effects of Ischemia-Reperfusion Injury in a Swine Model of Lung Transplantation

Table 2

Histological lung injury score.

		Baseline	Back table	Postreperfusion
Alveolar edema	Control	0 (0; 0)	0 (0; 0)	2 (0.25; 2)
	SEV	0 (0; 0)	0 (0; 0)	0,5 (0; 1)^a
Interstitial edema	Control	0 (0; 0)	0 (0; 0)	1 (0; 2)
	SEV	0 (0; 0)	0 (0; 1)	1 (1; 1.75)
Alveolar neutrophil infiltration	Control	0 (0; 0)	0,5 (0; 1.25)	0,5 (0; 1)
	SEV	0 (0; 0)	0 (0; 0)	1 (0; 1)
Perivascular neutrophil infiltrate	Control	0 (0; 0)	0,5 (0; 1)	1 (0.25; 1)
	SEV	0 (0; 0)	0 (0; 0)^a	0 (0; 0)^a
Interstitial hemorrhage	Control	0 (0; 0)	0 (0; 0)	0 (0; 0.75)
	SEV	0 (0; 0.75)	0 (0; 0)	0 (0; 0)
Fibrin and hyaline deposits	Control	0 (0; 0)	0 (0; 0)	0 (0; 0)
	SEV	0 (0; 0)	0 (0; 1)	0 (0; 0.75)
Chronic infiltrate	Control	2 (1; 2)	1,5 (0.75; 2.25)	2 (1; 2)
	SEV	1,5 (1; 2)	2 (1; 2)	2 (1; 2)
Dense fibrosis	Control	0 (0; 0.75)	0 (0; 0.25)	0 (0; 0)
	SEV	0 (0; 0)	0 (0; 0)	0 (0; 0)
Total lung injury score	Control	2 (1; 2.75)	2,5 (0.75; 4.75)	6,5 (1.5; 8.75)
	SEV	1,5 (1; 2.75)	2 (1; 4)	4 (2.25; 6.5)

Control: control groups; SEV: sevoflurane treatment groups. Values are medians and interquartile (25%-75%) range. ^a vs. control.