Donor Preconditioning with Inhaled Sevoflurane Mitigates the Effects of Ischemia-Reperfusion Injury in a Swine Model of Lung Transplantation
Table 3
BAL levels of IL-12, IL-10, TGF-β, TNFα, IL-8, IL-6, and IL-1β in animal donor (baseline) and animal recipient after 2 and 6 hours of reperfusion.
Baseline
2 h reperfusion
6 h reperfusion
IL-12
Control
7.14 (4.6; 12.3)
9.71 (2.7; 41.8)
120.42 (110.6; 152.5)
SEV
36.25 (0; 93.1)
58.33 (3.7; 98.9)
57.5 (46.0; 80.4)a
IL-10
Control
0 (0; 0)
0 (0; 25.3)
0 (0; 0)
SEV
0 (0; 0)
62.35 (0; 74.8)a
17.10 (0; 34.4)a
TGF-β
Control
0 (0; 0)
43.58 (0; 107.4)
0 (0; 71.2)
SEV
0 (0; 0)
0 (0; 0)a
0 (0; 0)
TNFα
Control
0 (0; 0.2)
270.42 (178.8; 414.2)
43.69 (0; 99.2)
SEV
0 (0; 0)
93.26 (44.7; 191.7)
19.64 (0; 65.5)
IL-8
Control
139.25 (116.1; 146.1)
825.5 (356.7; 1263)
203 (154.2; 384.2)
SEV
92.7 (0; 204.2)
21.875 (0; 120.6)a
137.5 (21.8; 146.2)a
IL-6
Control
2.07 (0; 6.5)
93 (52.4; 338.7)
130.30 (77.2; 1032.2)
SEV
0 (0; 0)
33.88 (0; 69.4)a
277.33 (97.7; 420.5)
IL-1β
Control
0 (0; 6.5)
255.625 (0; 259.2)
35.5 (11.1; 372.3)
SEV
0 (0; 14.3)
14.5 (0; 77.5)
168.5 (74.8; 343.1)
Control: control groups; SEV: sevoflurane treatment groups. Values are medians and interquartile (25%-75%) range and are presented as concentration (pg/ml). a vs. control.
