The Natural History and Reperfusion Therapy Outcomes of Acute Ischemic Stroke due to Isolated M2 Occlusions

Table 3

Efficacy and safety outcomes according to treatment methods.

Characteristic	NRT	IVT	EVT	Unadjusted value (95% CI); value	Adjusted value (95% CI)^†: value
Primary efficacy outcome
Delta NIHSS score, median (IQR)	-1 (-2.5 to 0)	-3 (-6 to 0)	-5 (-10.25 to -3.75)	-0.98 (-3.18 to 1.22); -4.26 (-6.71 to -1.81); ^#; -3.28 (-5.69 to -0.87); ^▲	-0.40 (-2.89 to 2.09); -4.01(-6.60 to -1.43); ^#; -3.61 (-6.45 to -0.77); ^▲
90-day mRS score, median (IQR)	4 (1, 5)	2 (1, 3)	1 (1, 2)	-1.13 (-2.04 to -0.22); -1.64 (-2.66 to -0.63); ^#; -0.52 (-1.52 to 0.48); ^▲	-0.67 (-1.65 to 0.32); -1.42 (-2.43 to -0.40); ^#; -0.75 (-1.87 to 0.37); ^▲
Secondary efficacy outcomes
90-day mRS score 0-2 (%)	11 (44.00)	20 (74.07)	16 (88.89)	3.64 (1.13-11.69); 10.18 (1.92-54.02); ^#; 2.80 (0.51-15.38); ^▲	2.23 (0.51-9.64); 8.73 (1.43-53.24); ^#; 6.38 (0.41-99.12); ^▲
FIV, median (IQR), ml	50.93 (8.55, 112.75)	30.77 (8.75, 55.270)	26.08 (6.78, 53.63)	-43.28 (-72.97 to -13.59); -37.24 (-70.32 to -4.17); ^#; 6.04(-26.52 to 38.59); ^▲	-8.63 (-37.67 to 20.41); -29.66 (-59.73 to 0.42); ^#; -21.03 (-54.12 to 12.07); ^▲
90-day mortality rate (%)	6 (24)	2 (7.41)	0	NA	NA
(%)	-	-	16 (88.89)	NA	NA
Safety outcomes
sICH (%)	0	4 (14.81)	0	NA	NA
Procedure-related complications (%)	-	-	1 (5.56)	NA	NA

Abbreviations: NRT: no reperfusion therapy; IVT: intravenous thrombolysis treatment; EVT: endovascular intervention; NIHSS: National Institutes of Health Stroke Scale; IQR: interquartile range; mRS: modified Rankin Scale; sICH: symptomatic intracerebral hemorrhage; aICH: asymptomatic intracerebral hemorrhage; mTICI: modified thrombolysis in cerebral ischemia score; FIV: final infarct volume (within 2-7 days after symptom onset); NA: not applicable; delta NIHSS score: change in the NIHSS score from baseline to 24 h. ^†Model adjusted for age, admission NIHSS score, and time from onset to treatment. A comparison was conducted between the NRT and IVT groups, and ^#comparison conducted between the NRT and EVT groups. ^▲A comparison was conducted between the IVT and EVT groups.