Quercetin Alleviates Intervertebral Disc Degeneration by Modulating p38 MAPK-Mediated Autophagy

<div>QUE attenuates the progression of IVDD in the rat tail needle puncture-induced IVDD model. (a) Representative T2-weighted images of MRI scans for the needle-punctured discs 4 and 8 weeks postsurgery (red boxes indicate the punctured level). (b) Pfirrmann grade scores based on the MRI T2-weighted signal intensity 4 and 8 weeks postsurgery. (c) Representative H&amp;E images showing the histopathology and cell morphology and Safranin-O/Fast Green and Alcian blue staining showing proteoglycan deposition in different experimental groups 8 weeks postsurgery (original magnification ×25, scale bar: 500 <i>μ</i>m). (d) The improved histopathological grading score of intervertebral discs were calculated for each group. 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0V27C293 34 287 42 287 114V635C232 613 172 594 109 583V559L157 557C201 555 205 550 205 499V114C205 42 199 34 109 27V0H384Z"></path></g></svg> vs. saline group.</div>

BioMed Research International

fig7

Figure 7

Figure 7: Quercetin Alleviates Intervertebral Disc Degeneration by Modulating p38 MAPK-Mediated Autophagy 