Shared Molecular Mechanisms between Alzheimer’s Disease and Periodontitis Revealed by Transcriptomic Analysis

Table 3

Topological characteristics of the top 30 nodes in the periodontitis-related PPI network, ranked in descending order of degree.

Node	Label	Degree	Average shortest path length	Betweenness centrality	Closeness centrality	Clustering coefficient	Topological coefficient
MYC	DEG_down	1027	2.432727	0.177217	0.411061	0.001896	0.002805
HSPB1	DEG_down	433	2.638061	0.059908	0.379066	0.00278	0.005213
SMAD3	DEG_up	396	2.667636	0.052167	0.374864	0.004283	0.005425
UBC		395	2.112	0.241673	0.473485	0.004524	0.007004
TRIM27	DEG_up	334	2.864727	0.046792	0.349073	0.000791	0.006306
VIM	DEG_up	320	2.705212	0.037607	0.369657	0.005251	0.007619
YWHAH	DEG_up	282	2.838788	0.034115	0.352263	0.001868	0.00865
DDB1	DEG_down	276	2.76497	0.029677	0.361668	0.003531	0.008012
RPS3	DEG_down	275	2.844848	0.015036	0.351513	0.019323	0.014779
KAT5	DEG_down	245	2.717697	0.028224	0.367959	0.00716	0.007732
SMARCA4	DEG_down	242	2.715758	0.021646	0.368221	0.010116	0.008636
RPL13	DEG_down	234	2.755152	0.015773	0.362956	0.024541	0.011238
PLCG1	DEG_down	227	2.885091	0.030011	0.34661	0.002144	0.009614
FOS	DEG_up	226	2.880727	0.024538	0.347135	0.003265	0.009974
AP2M1	DEG_down	214	2.850182	0.025582	0.350855	0.007635	0.010848
SF3B3	DEG_down	203	2.765576	0.015188	0.361588	0.014583	0.010661
TP53RK	DEG_up	200	2.871394	0.013972	0.348263	0.01608	0.012798
MMS19	DEG_down	195	2.806909	0.022335	0.356264	0.004705	0.008763
RPS7	DEG_down	193	2.88303	0.008126	0.346857	0.028335	0.016367
MEPCE	DEG_down	189	2.905212	0.0145	0.344209	0.005066	0.012337
TUBB4B	DEG_down	173	2.880364	0.008167	0.347178	0.007595	0.019412
CDH1	DEG_down	171	2.888485	0.016186	0.346202	0.005848	0.011775
EZR	DEG_down	170	2.906667	0.016295	0.344037	0.004107	0.01554
DDX41	DEG_down	168	2.950061	0.009545	0.338976	0.007057	0.017509
NUDC	DEG_up	160	2.943758	0.016886	0.339702	0.00283	0.013954
SF3A2	DEG_down	156	2.949818	0.009075	0.339004	0.009926	0.01593
RPL27	DEG_down	147	2.912727	0.003949	0.343321	0.043985	0.020057
NIFK	DEG_up	145	3.107879	0.011111	0.321763	0.010345	0.016053
SRPRB	DEG_up	143	2.945333	0.017545	0.33952	0.001674	0.015983
ATP1A1	DEG_up	140	2.816606	0.011269	0.355037	0.009147	0.013032