Shared Molecular Mechanisms between Alzheimer’s Disease and Periodontitis Revealed by Transcriptomic Analysis

Table 4

The 51 crosstalk genes that were upregulated and 41 crosstalk genes which were downregulated in periodontitis.

Regulation pattern in periodontitis	Crosstalk genes linking periodontitis and Alzheimer’s disease
Upregulated	AMIGO1 (adhesion molecule with Ig-like domain 1; gene ID: 57463); ARG2 (arginase 2; gene ID: 384); BDKRB2 (bradykinin receptor B2; gene ID: 624); BRI3 (brain protein I3; gene ID: 25798); C1D (C1D nuclear receptor corepressor; gene ID: 10438); C3 (complement C3; gene ID: 718); C4A (complement C4A (Rodgers blood group); gene ID: 720); C4B (complement C4B; gene ID: 721); C4B_2 (complement component 4B (Chido blood group), copy 2; gene ID: 100293534); CASP7 (caspase 7; gene ID: 840); CD177 (CD177 molecule; gene ID: 57126); CD38 (CD38 molecule; gene ID: 952); CHCHD10 (coiled-coil-helix-coiled-coil-helix domain containing 10; gene ID: 400916); COX8A (cytochrome c oxidase subunit 8A; gene ID: 1351); CSF3 (colony-stimulating factor 3; gene ID: 1440); CTGF (cellular communication network factor 2; gene ID: 1490); CTSS (cathepsin S; gene ID: 1520); CXCL1 (C-X-C motif chemokine ligand 1; gene ID: 2919); CXCL12 (C-X-C motif chemokine ligand 12; gene ID: 6387); CXCL8 (C-X-C motif chemokine ligand 8; gene ID: 3576); CXCR4 (C-X-C motif chemokine receptor 4; gene ID: 7842); ENPP2 (ectonucleotide pyrophosphatase/phosphodiesterase 2; gene ID: 5168); FCGR3A (Fc fragment of IgG receptor IIIa; gene ID: 2214); FCGR3B (Fc fragment of IgG receptor IIIb; gene ID: 2215); FHL2 (four and a half LIM domains 2; gene ID: 2274); FOS (Fos proto-oncogene, AP-1 transcription factor subunit; gene ID: 2353); FOXO1 (forkhead box O1; gene ID: 2308); GSTK1 (glutathione S-transferase kappa 1; gene ID: 373156); GSTO1 (glutathione S-transferase omega 1; gene ID: 9446); HCLS1 (hematopoietic cell-specific Lyn substrate 1; gene ID: 3059); IGFBP7 (insulin-like growth factor binding protein 7; gene ID: 3490); IL1B (interleukin-1 beta; gene ID: 3553); LYZ (lysozyme; gene ID: 4069); MAK16 (MAK16 homolog; gene ID: 84549); MEF2C (myocyte-specific enhancer factor 2C; gene ID: 4208); MME (membrane metalloendopeptidase; gene ID: 4311); MMP1 (matrix metallopeptidase 1; gene ID: 4312); MMP3 (matrix metallopeptidase 3; gene ID: 4314); MS4A1 (membrane-spanning 4-domains A1; gene ID: 931); MSRA (methionine sulfoxide reductase A; gene ID: 4482); MZB1 (marginal zone B and B1 cell-specific protein; gene ID: 51237); NDUFB8 (NADH:ubiquinone oxidoreductase subunit B8; gene ID: 4714); PECAM1 (platelet endothelial cell adhesion molecule 1; gene ID: 5175); PLAT (plasminogen activator, tissue type; gene ID: 5327); PSENEN (presenilin enhancer, gamma-secretase subunit; gene ID: 55851); SEL1L (SEL1L adaptor subunit of ERAD E3 ubiquitin ligase; gene ID: 6400); SERPINI1 (serpin family I member 1; gene ID: 5274); ST6GAL1 (ST6 beta-galactoside alpha-2,6-sialyltransferase 1; gene ID: 6480); VCAN (versican; gene ID: 1462); VIM (vimentin; gene ID: 7431); WARS2 (tryptophanyl tRNA synthetase 2, mitochondrial; gene ID: 10352)
Downregulated	ABCA12 (ATP binding cassette subfamily A member 12; gene ID: 26154); ACE (angiotensin I converting enzyme; gene ID: 1636); ADRB1 (adrenoceptor beta 1; gene ID: 153); BCL2L2 (BCL2-like 2; gene ID: 599); BRSK1 (BR serine/threonine kinase 1; gene ID: 84446); CALML5 (calmodulin-like 5; gene ID: 51806); CALR (calreticulin; gene ID: 811); CD36 (CD36 molecule; gene ID: 948); CDH1 (cadherin 1; gene ID: 999); CDK5R1 (cyclin-dependent kinase 5 regulatory subunit 1; gene ID: 8851); CTDSP2 (CTD small phosphatase 2; gene ID: 10106); DNM1 (dynamin 1; gene ID: 1759); DSG1 (desmoglein 1; gene ID: 1828); FLG (filaggrin; gene ID: 2312); GJA1 (gap junction protein alpha 1; gene ID: 2697); GRHL3 (grainyhead-like transcription factor 3; gene ID: 57822); GRIN3B (glutamate ionotropic receptor NMDA type subunit 3B; gene ID: 116444); HM13 (histocompatibility minor 13; gene ID: 81502); HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase; gene ID: 3156); HSPB1 (heat shock protein family B (small) member 1; gene ID: 3315); KAT5 (lysine acetyltransferase 5; gene ID: 10524); MAP3K12 (mitogen-activated protein kinase kinase kinase 12; gene ID: 7786); MED12 (mediator complex subunit 12; gene ID: 9968); MFN2 (mitofusin 2; gene ID: 9927); MYC (MYC proto-oncogene, bHLH transcription factor; gene ID: 4609); NEFL (neurofilament light; gene ID: 4747); NES (exportin 1; gene ID: 7514); NGF (nerve growth factor; gene ID: 4803); NOS3 (nitric oxide synthase 3; gene ID: 4846); NPTXR (neuronal pentraxin receptor; gene ID: 23467); PLXNA3 (plexin A3; gene ID: 55558); PPIL2 (peptidylprolyl isomerase-like 2; gene ID: 23759); PTGS1 (prostaglandin-endoperoxide synthase 1; gene ID: 5742); RPL13 (ribosomal protein L13; gene ID: 6137); SCIMP (SLP adaptor and CSK interacting membrane protein; gene ID: 388325); SPPL2B (signal peptide peptidase-like 2B; gene ID: 56928); TIAF1 (TGFB1-induced antiapoptotic factor 1; gene ID: 9220); TP73 (tumor protein P73; gene ID: 7161); TYRP1 (tyrosinase-related protein 1; gene ID: 7306); USF2 (upstream transcription factor 2, C-Fos interacting; gene ID: 7392); VEGFA (vascular endothelial growth factor A; gene ID: 7422)