Shared Molecular Mechanisms between Alzheimer’s Disease and Periodontitis Revealed by Transcriptomic Analysis

Table 5

Topological characteristics of the top 30 nodes in the crosstalk gene-related PPI network, ranked in descending order of degree.

Node	Label	Degree	Average shortest path length	Betweenness centrality	Closeness centrality	Clustering coefficient	Topological coefficient
MYC	DEG_AD_down	1027	2.127525	0.466698	0.47003		0.001842
HSPB1	DEG_AD_down	433	2.36959	0.184598	0.422014	0.001636	0.003351
VIM	DEG_AD_up	320	2.663301	0.116611	0.375474	0.001763	0.005783
KAT5	DEG_AD_down	245	2.566359	0.089476	0.389657	0.003011	0.005621
RPL13	DEG_AD_down	234	2.589729	0.089708	0.386141	0.001394	0.005672
FOS	DEG_AD_up	226	2.883151	0.083642	0.346843		0.017606
CDH1	DEG_AD_down	171	2.93191	0.058428	0.341075	0	0.025911
TP73	DEG_AD_down	137	2.61483	0.046781	0.382434	0.006333	0.009173
FHL2	DEG_AD_up	136	2.641085	0.057192	0.378632	0.004031	0.00889
CALR	DEG_AD_down	135	2.812464	0.046142	0.35556	0.002764	0.010949
GSTK1	DEG_AD_up	111	2.988459	0.035152	0.334621	0	0.026289
MME	DEG_AD_up	104	2.836988	0.040386	0.352487	0.001307	0.011694
MED12	DEG_AD_down	91	2.695615	0.030682	0.370973	0.006105	0.012517
CASP7	DEG_AD_up	90	2.901039	0.027131	0.344704	0.005243	0.015603
DNM1	DEG_AD_down	84	2.960185	0.029086	0.337817	0.001147	0.023716
FOXO1	DEG_AD_up	67	2.977784	0.017403	0.33582	0.004071	0.026586
CXCR4	DEG_AD_up	65	2.998557	0.020851	0.333494	0.003846	0.028808
NOS3	DEG_AD_down	62	2.963647	0.018786	0.337422	0.002644	0.027957
NDUFB8	DEG_AD_up	56	3.042412	0.02136	0.328687	0	0.027447
UBC	Other gene	53	2.084824	0.149265	0.479657	0.015965	0.027336
NES	DEG_AD_down	53	2.920946	0.017012	0.342355	0.007983	0.022954
CDK5R1	DEG_AD_down	50	3.0176	0.0133	0.331389	0.002449	0.037222
NEFL	DEG_AD_down	49	2.913445	0.014886	0.343236	0.008503	0.024673
C3	DEG_AD_up	43	3.043278	0.01705	0.328593	0	0.042101
SEL1L	DEG_AD_up	42	3.036065	0.013066	0.329374	0	0.045635
DSG1	DEG_AD_down	41	3.046163	0.00857	0.328282	0	0.068464
GJA1	DEG_AD_down	41	3.035199	0.015703	0.329468	0	0.04037
MEF2C	DEG_AD_up	41	3.039238	0.008676	0.32903	0	0.068892
LYZ	DEG_AD_up	40	3.042123	0.008578	0.328718	0	0.065086
GSTO1	DEG_AD_up	38	2.820254	0.010905	0.354578	0.019915	0.030356