Shared Molecular Mechanisms between Alzheimer’s Disease and Periodontitis Revealed by Transcriptomic Analysis

Table 7

Topological characteristics of the top 30 nodes in the TF-crosstalk gene target network, ranking in descending order.

Node	Label	Degree	Average shortest path length	Betweenness centrality	Closeness centrality	Clustering coefficient	Topological coefficient
FOS	DEG_up&TF	89	2.178295	0.206101	0.459075	0.020429	0.03825
VEGFA	DEG_down	77	2.211886	0.197219	0.452103	0.010936	0.038456
MEF2C	DEG_up&TF	76	2.328165	0.159945	0.429523	0.004211	0.044258
CDH1	DEG_down	69	2.540052	0.159392	0.393693	0	0.086634
CXCR4	DEG_up	47	2.596899	0.075105	0.385075		0.083836
MME	DEG_up	44	2.664083	0.04365	0.375364	0	0.131313
C4A	DEG_up	38	2.661499	0.029742	0.375728	0.01138	0.118617
VIM	DEG_up	38	2.521964	0.060293	0.396516	0.012802	0.065789
CSF3	DEG_up	36	2.550388	0.031734	0.392097	0.019048	0.075137
C4B	DEG_up	34	2.679587	0.018887	0.373192	0.012478	0.122037
VCAN	DEG_up	34	2.726098	0.030567	0.366825	0	0.143717
IL1B	DEG_up	33	2.741602	0.05746	0.36475	0	0.134602
BRSK1	DEG_down	30	2.741602	0.030404	0.36475	0	0.153788
SERPINI1	DEG_up	29	2.793282	0.019014	0.358002	0	0.127586
USF2	DEG_down&TF	27	2.591731	0.027575	0.385842	0.045584	0.081607
GRHL3	DEG_down	27	2.775194	0.027067	0.360335	0	0.150732
HSPB1	DEG_down	26	2.780362	0.017981	0.359665	0	0.155678
MMP3	DEG_up	26	2.607235	0.024377	0.383548	0.036923	0.074984
CTGF	DEG_up	25	2.788114	0.020669	0.358665	0	0.161905
HMGCR	DEG_down	25	2.767442	0.041119	0.361345	0	0.16
GATA2	TF	24	2.095607	0.052687	0.477189	0.018116	0.104678
PLAT	DEG_up	24	2.762274	0.028075	0.362021	0	0.173148
ETS1	TF	22	2.273902	0.03767	0.439773	0.012987	0.092022
NPTXR	DEG_down	22	2.826873	0.020478	0.353748	0	0.154545
AR	TF	21	2.24031	0.040698	0.446367	0.02381	0.105465
YBX1	TF	21	2.315245	0.037801	0.43192	0.004762	0.098928
BCL2L2	DEG_down	21	2.813953	0.018179	0.355372	0	0.144048
FCGR3A	DEG_up	21	2.81137	0.020521	0.355699	0	0.192799
ABCA12	DEG_down	20	2.79845	0.010961	0.357341	0	0.2
SP1	TF	20	2.191214	0.037362	0.456368	0.026316	0.109167
CDK5R1	DEG_down	20	2.824289	0.017878	0.354071	0	0.156098
FLG	DEG_down	20	2.653747	0.012281	0.376826	0.042105	0.093043