Transfer of Th17 from Adult Spontaneous Hypertensive Rats Accelerates Development of Hypertension in Juvenile Spontaneous Hypertensive Rats

Figure 1

The systolic blood pressure (SBP), body weight, and serum levels of cytokines in Wistar-Kyoto rats (WKY) and spontaneous hypertensive rats (SHR). (a) SBP was measured using the tail-cuff method. SBP of SHR significantly higher at adult (15 weeks) compared with juvenile (5 weeks). (b) The body weights of the WKY and SHR revealed comparable in 5 weeks and 15 weeks. The serum levels of (c) a proinflammatory cytokine (IL-17A) and (d) an anti-inflammatory cytokine (IL-10) were measured using ELISA in juvenile and adult rats. The serum levels of IL-17A were higher in SHR than in WKY, whereas the levels of IL-10 were lower in SHR than in WKY. Data are the of 6 independent experiments. Most SEMs were too small to be seen out of symbols (, vs. WKY; ^## vs. corresponding juvenile rats by two-way ANOVA followed by the post hoc Duncan test).

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