Genetic Variants of lncRNA GAS5 Contribute to Susceptibility of Ischemic Stroke among Southern Chinese Population
Table 2
Frequencies of lncRNA GAS5 genotypes and alleles in IS patients and controls.
Genotypes
IS patients, (%)
Controls, (%)
AOR (95% CI)
value
valuea
rs145204276
ins/ins(II)
424 (39.0)
486 (46.5)
0.0020
ins/del(ID)
528 (48.6)
465 (44.5)
del/del(DD)
134 (12.3)
94 (9.0)
Dominant model DD+ID vs. II
662 (61.0)
559 (53.5)
1.36 (1.14-1.61)
0.0020
Recessive model II+ID vs. DD
952 (87.7)
951 (91.0)
0.70 (0.53-0.93)
0.013
0.026
ins allele
1376 (63.4)
1437 (68.8)
del allele
796 (36.6)
653 (31.2)
1.27 (1.12-1.45)
0.0016
rs55829688
TT
579 (53.3)
517 (49.5)
0.20
0.23
TC
415 (38.2)
430 (41.1)
CC
92 (8.5)
98 (9.4)
Dominant model TC+CC vs. TT
507 (46.7)
528 (50.5)
0.86 (0.72-1.02)
0.076
0.12
Recessive model TT+TC vs. CC
994(91.5)
947(90.6)
1.12(0.83-1.51)
0.46
0.46
T allele
1573(72.9)
1464(70.0)
C allele
599(27.1)
626(30.0)
0.89(0.78-1.02)
0.087
0.12
value of difference in genotypes between the case group and control group. is indicated in bold font. Adjusted for age, gender, smoking, hypertension, diabetes mellitus, and hyperlipidaemia. aFalse discovery rate-adjusted value for multiple hypotheses testing using the Benjamini-Hochberg method. AOR: adjusted odds ratio; CI: confidence interval; DD: del/del; ID: ins/del; II: ins/ins; IS: ischemic stroke; lncRNA: long noncoding RNA.
