Genetic Variants of lncRNA GAS5 Contribute to Susceptibility of Ischemic Stroke among Southern Chinese Population
Table 4
Stratified analysis between the genotypes and alleles of lncRNA GAS5 rs145204276 polymorphism among IS patients and the control group.
Characteristics
IS patient group
Control group
a value
a value
Genotype, (%)
Allele, (%)
Genotype, (%)
Allele, (%)
II
ID
DD
I
D
II
ID
DD
I
D
Age
≥65
237 (38.5)
286 (46.5)
92 (15.0)
760 (61.8)
470 (38.2)
265 (47.1)
243 (43.2)
55 (9.8)
773 (68.7)
353 (31.3)
0.0077
0.0018
<65
187 (39.7)
242 (51.4)
42 (8.9)
616 (65.4)
326 (34.6)
221 (45.9)
222 (46.0)
39 (8.1)
664 (68.9)
300 (31.1)
0.20
0.12
Gender
Male
281 (38.1)
359 (48.6)
98 (13.3)
921 (62.4)
555 (37.6)
232 (45.4)
234 (45.8)
45 (8.8)
698 (68.3)
324 (31.7)
0.019
0.0050
Female
142 (40.8)
170 (48.9)
36 (10.3)
454 (65.2)
242 (34.8)
254 (47.5)
231 (43.3)
49 (9.2)
739 (69.2)
329 (30.8)
0.20
0.11
Smoking
Yes
101 (38.5)
149 (46.7)
54 (14.8)
351 (57.7)
257 (42.3)
63 (50.4)
52 (41.6)
10 (8.0)
178 (71.2)
72 (28.8)
0.0065
0.0018
No
323 (39.2)
379 (49.4)
80 (11.4)
1025 (65.5)
539 (34.4)
423 (46.0)
413 (44.9)
84 (9.1)
1259 (68.4)
581 (31.6)
0.20
0.11
Diabetes
Yes
130 (39.6)
179 (46.4)
57 (14.0)
460 (62.8)
272 (37.2)
55 (47.8)
49 (42.6)
11 (9.6)
159 (69.1)
71 (30.9)
0.090
0.11
No
294 (38.8)
349 (49.7)
77 (11.5)
916 (63.6)
524 (36.4)
431(46.4)
416 (44.7)
83 (8.9)
1278 (68.7)
582 (31.3)
0.12
0.0050
Hypertension
Yes
295 (35.6)
418 (50.5)
115 (13.9)
1008 (60.9)
648 (39.1)
158 (46.3)
152 (44.6)
31 (9.1)
468 (68.6)
214 (31.4)
0.0065
0.0018
No
129 (50.0)
110 (42.6)
19 (7.4)
368 (71.3)
148 (28.7)
328 (46.6)
313 (44.5)
63 (8.9)
969 (68.8)
439 (31.2)
0.58
0.31
DD: del/del; GAS5: growth arrest special 5; ID: ins/del; II: ins/ins; IS: ischemic stroke; lncRNA: long noncoding RNA. : value of the difference in genotypes between the case and control groups; : value of the difference in alleles between the case and control groups; afalse discovery rate-adjusted value for multiple hypotheses testing using the Benjamini-Hochberg method. is indicated in bold font.
