Genetic Variants of lncRNA GAS5 Contribute to Susceptibility of Ischemic Stroke among Southern Chinese Population
Table 5
Stratified analysis between the genotypes and alleles of lncRNA GAS5 rs55829688 polymorphism among IS patients and the control group.
Characteristics
IS patient group
Control group
a value
a value
Genotype, (%)
Allele, (%)
Genotype, (%)
Allele, (%)
TT
TC
CC
T
C
TT
TC
CC
T
C
Age
≥65
315 (50.4)
244 (40.5)
56 (9.1)
874 (71.1)
356 (28.9)
278 (49.4)
230 (40.8)
55 (9.8)
786 (69.8)
340 (30.2)
0.89
0.62
<65
264 (56.1)
171 (36.3)
36 (7.6)
699 (74.2)
243 (25.8)
239 (49.6)
200 (41.5)
43 (8.9)
678 (70.3)
286 (29.7)
0.64
0.35
Gender
Male
390 (52.8)
289 (39.2)
59 (8.0)
1069 (72.4)
407 (27.6)
259 (50.7)
211 (41.3)
41 (8.0)
729 (71.3)
293 (28.7)
0.93
0.62
Female
189 (54.3)
126 (36.2)
33 (9.5)
504 (72.4)
192 (27.6)
258 (48.3)
219 (41.0)
57 (10.7)
735 (68.8)
333 (31.2)
0.64
0.35
Smoking
Yes
167 (54.9)
105 (34.5)
32 (10.5)
439 (72.2)
169 (27.8)
60 (48.0)
53 (42.4)
12 (9.6)
173 (69.2)
77 (30.8)
0.64
0.62
No
412 (52.7)
310 (39.6)
60 (7.7)
1134 (72.5)
430 (27.5)
457 (49.7)
377 (41.0)
86 (9.3)
1291 (70.2)
549 (29.8)
0.64
0.35
Diabetes
Yes
191 (52.2)
140 (38.3)
35 (9.5)
522 (71.3)
210 (28.7)
55 (47.8)
48 (41.7)
12 (10.5)
158 (68.7)
72 (31.3)
0.93
0.62
No
388 (53.9)
275 (38.2)
57 (7.9)
1051 (73.0)
389 (27.0)
462 (49.7)
382 (41.1)
86 (9.2)
1306 (70.2)
554 (29.8)
0.64
0.35
Hypertension
Yes
442 (53.4)
316 (38.1)
70 (8.5)
1200 (72.5)
456 (27.5)
177 (51.9)
134 (42.2)
30 (8.8)
488 (71.6)
194 (28.4)
0.89
0.68
No
137 (53.1)
99 (38.4)
22 (8.5)
373 (72.3)
143 (27.7)
340 (50.0)
296 (40.6)
68 (9.4)
976 (69.3)
432 (30.7)
0.43
0.44
GAS5: growth arrest special 5; IS: ischemic stroke; lncRNA: long noncoding RNA. : value of the difference in genotypes between the case and control groups; : value of the difference in alleles between the case and control groups; afalse discovery rate-adjusted value for multiple hypotheses testing using the Benjamini-Hochberg method.
