Neutrophil-Lymphocyte Ratio as an Initial Screening Biomarker for Differential Diagnosis of Cushing’s Syndrome from Nonfunctional Adenoma in Patients with an Adrenal Mass

Table 1

Baseline characteristics of the CS and nonfunctional adrenal mass groups.

	CS ()	Nonfunctional ()	value
Male (%)	61 (32.97%)	61 (32.97%)	—
Age (years)			<0.001
BMI (kg/m^2)			0.947
Hypertension (%)	151 (81.62%)	124 (67.03%)	0.001
Diabetes (%)	63 (34.05%)	51 (27.57%)	0.177
SBP (mmHg)			0.002
DBP (mmHg)			<0.001
HbA1c (%)	6.0 (5.7, 6.8)	6.0 (5.7, 6.6)	0.573
FPG (mmol/L)	5.31 (4.72, 6.34)	5.47 (5.04, 6.30)	0.141
Plasma K+ (mmol/L)			<0.001
TG (mmol/L)			0.315
TCHO (mmol/L)			<0.001
8 am serum cortisol (μg/dL)	16.92 (12.32, 23.99)	12.35 (9.71, 16.87)	<0.001
4 pm serum cortisol (μg/dL)	13.61 (8.87, 21.52)	6.66 (5.11, 9.62)	<0.001
0 am serum cortisol (μg/dL)	11.67 (6.33, 19.35)	2.67 (1.77, 4.50)	<0.001
8 am ACTH (pg/mL)	2.00 (0.99, 7.74)	18.54 (12.30, 26.62)	<0.001
4 pm ACTH (pg/mL)	1.57 (0.99, 4.47)	10.72 (7.51, 15.96)	<0.001
0 am ACTH (pg/mL)	1.30 (0.99, 2.93)	6.99 (3.97, 11.72)	<0.001
Urine cortisol (μg/24 h)	963.3 (568.1, 1850.0)	539.8 (412.2, 717.9)	<0.001
CRP (mg/L)	0.79 (0.30, 1.89)	1.24 (0.65, 2.33)	0.001
Longest diameter of adrenal nodule (cm)	2.70 (2.20, 3.60)	1.60 (1.00, 2.30)	<0.001

Results are presented as the , median (interquartile range), or (%). Abbreviations: CS: Cushing’s syndrome; BMI: body mass index; SBP: systolic blood pressure; DBP: diastolic blood pressure; FPG: fasting plasma glucose; TG: triglyceride; TCHO: total cholesterol; ACTH: corticotropin; CRP: C-reactive protein.