Neutrophil-Lymphocyte Ratio as an Initial Screening Biomarker for Differential Diagnosis of Cushing’s Syndrome from Nonfunctional Adenoma in Patients with an Adrenal Mass

Table 3

Comparison of different initial screen markers used to diagnose CS.

	Sensitivity	Specificity	Weighted Youden index^△
0 am serum cortisol (μg/dL)	98.8%	26.6%	0.543
24-hour urine free cortisol	67.1%	70.5%	0.362
Serum cortisol after 1 mg DST (μg/dL)	100%	89.1%	0.935
NLR	80.0%	54.1%	0.445

Abbreviations: DST: dexamethasone suppression test; NLR: neutrophil-lymphocyte ratio; CS: Cushing’s syndrome. and , vs. NLR.
^△weighted coefficient of sensitivity ω = 0.7.