The Combination of Zerumbone and 5-FU: A Significant Therapeutic Strategy in Sensitizing Colorectal Cancer Cells to Treatment

Figure 4

The effect of ZER on the expression of survivin, vimentin, and β-catenin genes in CRC cell lines. Relative expression of (a) HCT-116 and (b) SW48 cells was determined using real-time PCR technique. The expression of survivin, vimentin, and β-catenin mRNA level was considerably reduced after 24 h in HCT-116 cells (a). The expression of survivin and vimentin mRNA level was considerably reduced after 72 h; however, β-catenin mRNA level was inhibited after 48 and 72 h in SW48 cells (b). 18srRNA was used as a normalizer. , , and compared to the control group ().

(a)

(b)