Long Noncoding RNA RP11-357H14.17 Plays an Oncogene Role in Gastric Cancer by Activating ATF2 Signaling and Enhancing Treg Cells

Figure 1

RP11-357H14.17 is overexpressed in human stomach cancer. (a) Heatmap of the all significantly differently expression lncRNAs (, cancer vs. normal, ). (b, c) Heatmaps of TOP 50 up and down-regulated significantly differently expressed lncRNAs; RP11-357H14.17 was highlighted with red font in (b). For (a–c), rows denote lncRNAs, and columns represent patients. Blue to red indicates a trend from low to high expression. Boxplot of comparison between cancer and normal control tissues (d) and cancer tissues with different TMN stages (e) in RP11-357H14.17 expression; the data is provided by TCGA-STAD. (f) Comparison of overall survival between RP11-357H14.17 high expression and low expression group; the data is provided by TCGA-STAD. (g) Boxplot of comparison between cancer and normal control tissues (left) and cancer tissues with different TMN stages for 52 paired human GC tissues (right). , for the left panel, unpaired test, and for the right panel, one-way ANOVA. (h) Prediction of subcellular location of RP11-357H14.17 provided by online tool lncLocator.

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