Oral Health, Caries Risk Profiles, and Oral Microbiome of Pediatric Patients with Leukemia Submitted to Chemotherapy

Table 1

Inclusion and exclusion criteria.

	Inclusion criteria	Exclusion criteria
ALL group	(i) Diagnosed with acute lymphoblastic leukemia based on bone marrow samples; (ii) Receiving CCLG-ALL 2008 chemotherapy regimen; (iii) No more than eighteen years old; (iv) Free of other systemic diseases; (v) Written informed consent	(i) Receiving antibiotics within 3 months before the study; (ii) Local antimicrobial treatment within 2 weeks; (iii) Without receiving stem cell transplantation
Healthy control group	(i) Age and socioeconomic status comparable with ALL patients; (ii) Free of systemic diseases; (iii) Written informed consent	(i) Systemic disorders that cause oral mucosal lesions or periodontal diseases; (ii) Receiving antibiotics within 3 months before the study; (iii) Local antimicrobial treatment within 2 weeks

ALL: patients with acute lymphoblastic leukemia.