Comparison of 1L Adjuvant Auxiliary Preparations with 2L Solely Polyethylene Glycol plus Ascorbic Acid Regime for Bowel Cleaning: A Meta-analysis of Randomized, Controlled Trials

Table 1

Baseline characteristics of included randomized controlled trials.

Study, year (country)	Source of patients	Experimental groups	1L,	2L,	Use of adjuvant	Time of first and last dose	Procedure time	Diet	Outcomes	Type of study
Kwon et al. [18], 2016 (Korea)	Outpatient	FD: Bis+0.5 L water; LD: water	91	96	20 mg bisacodyl	FD: 8 pm day-prior; LD: 6 am day-of	≥3 h interval before	3-day low residual	BBPS	Multicenter, single-blind, RCT
Kang et al. [19], 2017 (Korea)	Outpatient	FD: Bis; LD:	100	100	10 mg bisacodyl	FD: 9 pm day-prior; LD: ≥4 h prior	9 am-13 pm	3-day low residual	BBPS, ABPS	Single-center, single-blind, RCT
Choi et al. [17], 2019 (Korea)	Outpatient	FD: LD:	130	130	2 mg prucalopride	FD: 7 pm day-prior; LD: ≥5 h prior	9 am-13 pm	3-day low residual	BBPS, ABPS	Single-center, single-blind, RCT
Kim et al. [20], 2019 (Korea)	Outpatient	FD: —; LD:	83	85	20 mg bisacodyl (suppository)	FD: —; LD: 5 am day-of	8 : 30 am-12 pm	1-day clear liquid	BBPS	Single-center, single-blind, RCT
Kim et al. [21], 2020 (Korea)	NA	FD: Bis; LD:	99	99	10 mg bisacodyl	FD: 9 pm day-prior; LD: ≥5 h prior	9 am-17 pm	3-day low residual	BBPS	Single-center, single-blind, RCT

ABPS: Aronchick Bowel Preparation Scale; BBPS: Boston Bowel Preparation Scale; Bis: bisacodyl; FD: first dose; LD: last dose; PEG-Asc: polyethylene glycol plus ascorbic acid; Pru: prucalopride; RCT: randomized controlled trial; 1 L: 1 L polyethylene glycol plus ascorbic acid with adjuvant drug; 2 L: 2 L polyethylene glycol plus ascorbic acid.