Minimally Invasive Embedding of Saturated MSU Induces Persistent Gouty Arthritis in Modified Rat Model

Figure 3

Gross changes in joint tissue and mechanical pain threshold in rats after MSU embedding. (a) The thickness of the synovium lateral to the patellar ligament in the rats. The synovium thickness of the MSU groups was greater than that of the sham groups ( for each group; two-tailed -test, , ). (b) No significant (NS) differences were detected between the sham groups and MSU groups ( for each group; two-tailed -test). (c) The 50%PWT of the wild-type littermates () is shown between the dotted lines ( g). The pain threshold of the MSU groups was significantly lower than that in the sham group within 96 hours ( for sham group; for MSU group; the two-tailed Mann–Whitney test was applied in the time point of 4 hours and 24 hours; a two-tailed -test was applied for other time points; Pre: ; 1 hour: , 2 hours: , 4 hours: , 24 hours: ; 48 hours: ; 72 hours: ; 96 hours: ). (d) No significant differences were detected between the MSU groups with different operation frequencies at all time points ( for each group; one-way ANOVA was applied for each time point; at all time points with different operation frequencies). The -axis represents time points before and after operations. Data shown as the .

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