Development of the Binary and Ternary Atorvastatin Solid Dispersions: In Vitro and In Vivo Investigations

Figure 2

PXRD spectra of (a) PEG binary systems, (b) P188 binary systems, and (c) ternary systems. ATR: untreated atorvastatin; PEG 10000: polyethylene glycol 10000; P188: poloxamer 188; PMB7: physical mixture (ATR : PEG 10000, 1 : 5); BS7: solid dispersion (ATR : PEG 10000,1 : 5); PMB9: physical mixture (ATR : P188, 1 : 1); BS9: solid dispersion (ATR : P188, 1 : 1); PMT1: physical mixture (ATR : P188 : PEG 10000, 1 : 1 : 5); TS1: solid dispersion (ATR : P188 : PEG 10000, 1 : 1 : 5).

(a)

(b)

(c)