Development of the Binary and Ternary Atorvastatin Solid Dispersions: In Vitro and In Vivo Investigations

Figure 5

Antihyperlipidemic activity in rats. TG: triglyceride; TC: cholesterol; HDLc: high-density lipoprotein cholesterol; HFD: high-fat diet; ATR: untreated atorvastatin; PEG 10000: polyethylene glycol 10000; P188: poloxamer 188; PMB7: physical mixture (ATR : PEG 10000, 1 : 5); BSD7: solid dispersion (ATR : PEG 10000, 1 : 5); PMB9: physical mixture (ATR : P188, 1 : 1); BSD9: solid dispersion (ATR : p188, 1 : 1); PMT1: physical mixture (ATR : P188 : PEG 10000, 1 : 1 : 5); TSD7: solid dispersion (ATR : P188 : PEG 10000, 1 : 1 : 5); BS7: solid dispersion (ATR : PEG10000, 1 : 5); BS9: solid dispersion (ATR : P188, 1 : 1); TS1: solid dispersion (ATR : P188 : PEG10000, 1 : 1 : 5). (Each point represents the level, , , , and , in each group).