Research Article
Predictive Performances of Blood Parameter Ratios for Liver Inflammation and Advanced Liver Fibrosis in Chronic Hepatitis B Infection
Table 1
Clinical characteristics of the study patients.
| | Variables | Total () | Inflammatory activity | Fibrosis stage | | G0-1 () | G2-3 () | value | S0-2 () | S3-4 () | value |
| | Age, years | 37 (30-44) | 37 (31-46) | 36 (30-44) | 0.103 | 36 (30-44) | 37 (31-45) | 0.410 | | Male, (%) | 284 (66.5) | 129 (64.2) | 175 (68.4) | 0.347 | 152 (64.1) | 152 (69.1) | 0.262 | | Serological parameters | | HBeAg positive, (%) | 279 (61.1) | 93 (46.3) | 186 (72.7) | <0.001 | 132 (55.7) | 147 (66.8) | 0.015 | | HBV DNA, log10 IU/ml) | 6.3 (4.1-7.3) | 4.9 (3.0-7.3) | 6.6 (5.3-7.4) | <0.001 | 6.4 (3.6-7.5) | 6.1 (4.5-7.0) | 0.543 | | ALT, U/L | 63.0 (32.0-163.0) | 37.0 (18.0-71.0) | 106.5 (48.3-286.0) | <0.001 | 53.0 (22.0-147.5) | 74.0 (38.3-195.2) | <0.001 | | AST, U/L | 46.0 (26.0-98.0) | 28.0 (20.0-45.5) | 75.5 (42.0-170.0) | <0.001 | 36.0 (22.0-89.5) | 58.0 (33.3-114.8) | <0.001 | | GGT, U/L | 38.0 (19.0-79.5) | 22.0 (14.5-39.0) | 63.0 (32.3-112.7) | <0.001 | 26.0 (15.0-52.0) | 55.5 (31.0-98.8) | <0.001 | | TBil, μmol/L | 15.1 (11.1-20.7) | 14.3 (11.1-17.9) | 15.9 (11.3-22.0) | 0.007 | 14.2 (10.6-18.2) | 16.7 (11.4-23.8) | <0.001 | | Albumin, g/L | 41.5 (38.5-44.0) | 42.8 (40.5-45.6) | 40.0 (37.0-43.5) | <0.001 | 42.2 (39.7-45.0) | 40.3 (37.3-43.6) | <0.001 | | Globulin, g/L | 29.0 (26.9-33.0) | 29.0 (26.0-32.0) | 30.0 (27.0-33.7) | 0.001 | 29.0 (26.0-32.0) | 30.0 (27.0-33.0) | 0.012 | | WBC, ×109/L | 5.1 (4.1-6.1) | 5.4 (4.1-6.3) | 5.0 (4.2-6.01) | 0.029 | 5.3 (4.3-6.2) | 4.9 (4.1-6.1) | 0.066 | | Neutrophil count, ×109/L | 2.7 (2.1-3.5) | 3.0 (2.2-3.8) | 2.5 (2.0-3.2) | <0.001 | 2.8 (2.3-3.6) | 2.6 (1.9-3.3) | 0.001 | | Monocyte count, ×109/L | 0.3 (0.3-0.4) | 0.3 (0.3-0.4) | 0.3 (0.3-0.4) | 0.239 | 0.3 (0.3-0.4) | 0.3 (0.3-0.4) | 0.439 | | Lymphocyte count, ×109/L | 1.8 (1.4-2.1) | 1.7 (1.4-2.1) | 1.8 (1.4-2.2) | 0.229 | 1.8 (1.5-2.1) | 1.8 (1.4-2.2) | 0.409 | | Platelet, ×109/L | 157 (124-192) | 177 (148-201) | 142 (110-177) | <0.001 | 177 (150-202) | 139 (99-166) | 0.001 | | Serological indexes | | PLR | 87.54 (66.49-111.22) | 97.26 (79.74-120.49) | 77.05 (58.49-101.86) | <0.001 | 97.46 (80.41-122.99) | 71.46 (54.30-98.11) | <0.001 | | NLR | 1.55 (1.17-2.02) | 1.63 (1.31-2.21) | 1.43 (1.08-1.82) | <0.001 | 1.59 (1.28-2.10) | 1.42 (1.05-1.86) | 0.001 | | MLR | 0.19 (0.15-2.02) | 0.18 (0.14-0.25) | 0.19 (0.15-0.25) | 0.985 | 0.19 (0.15-0.25) | 0.19 (0.14-0.25) | 0.147 | | APRI | 0.81 (0.40-1.65) | 0.41 (0.27-0.75) | 1.34 (0.73-2.37) | <0.001 | 0.53 (0.29-1.23) | 1.09 (0.61-2.12) | <0.001 | | FIB-4 | 1.41 (0.97-2.39) | 1.09 (0.80-1.52) | 1.81 (1.24-3.38) | <0.001 | 1.21 (0.87-1.67) | 1.85 (1.19-3.51) | <0.001 | | GPR | 0.25 (0.12-0.66) | 0.13 (0.08-0.23) | 0.49 (0.23-1.10) | <0.001 | 0.15 (0.08-0.31) | 0.43 (0.23-0.95) | 0.001 |
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ALT: alanine aminotransferase; AST: aspartate aminotransferase; GGT: gamma-glutamyl transpeptidase; TBil: total bilirubin; WBC: white blood cell.
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