Predictive Performances of Blood Parameter Ratios for Liver Inflammation and Advanced Liver Fibrosis in Chronic Hepatitis B Infection

Table 3

Predictive performance of serological indexes for assessing liver inflammatory.

	AUROC (95% CI)	value	Cut-off	Se (%)	Sp (%)	PPV (%)	NPV (%)	Accuracy (%)	value
PLR
G2-3	0.676 (0.631-0.719)	<0.0001	74.27	46.9	83.0	54.2	78.5	62.6	—
G3	0.705 (0.661-0.747)	<0.0001	68.75	56.6	79.6	54.2	83.9	72.9	—
NLR
G2-3	0.616 (0.570-0.661)	<0.0001	1.36	45.7	72.6	41.7	75.7	57.3	0.044
G3	0.569 (0.523-0.615)	0.0337	1.85	79.8	33.8	34.0	79.5	57.8	0.0001
APRI
G2-3	0.838 (0.801-0.870)	<0.0001	0.65	79.3	73.1	55.8	89.2	76.4	<0.0001
G3	0.768 (0.727-0.806)	<0.0001	0.68	91.9	51.4	44.8	93.7	60.6	0.094
FIB-4
G2-3	0.752 (0.710-0.791)	<0.0001	1.48	65.6	75.1	53.1	83.6	69.8	0.009
G3	0.749 (0.706-0.788)	<0.0001	1.53	76.8	62.3	46.6	86.2	58.6	0.269
GPR
G2-3	0.822 (0.784-0.856)	<0.0001	0.25	72.7	79.6	60.4	87.2	75.5	<0.0001
G3	0.798 (0.759-0.834)	<0.0001	0.29	86.9	65.6	52.0	92.1	70.7	0.009

AUROC: area under ROC; Se: sensitivity; Sp: specificity; PPV: positive predictive value; NPV: negative predictive value. Compared with PLR.