Predictive Performances of Blood Parameter Ratios for Liver Inflammation and Advanced Liver Fibrosis in Chronic Hepatitis B Infection

Table 4

Predictive performance of serological indexes for assessing liver fibrosis.

	AUROC (95% CI)	value	Cut-off	Se (%)	Sp (%)	PPV (%)	NPV (%)	Accuracy	value
PLR
S3-4	0.723 (0.697-0.764)	<0.0001	79.67	59.6	78.0	53.7	81.8	68.9	—
S4	0.757 (0.715-0.796)	<0.0001	74.27	64.2	80.4	58.4	83.9	75.1	—
NLR
S3-4	0.590 (0.544-0.636)	0.0007	1.14	32.7	83.5	46.0	74.3	59.1	<0.0001
S4	0.546 (0.499-0.592)	0.123	—	—	—	—	—	—	—
APRI
S3-4	0.701 (0.657-0.743)	<0.0001	0.51	83.2	48.1	40.7	87.0	64.7	0.448
S4	0.716 (0.672-0.757)	<0.0001	0.66	80.0	52.8	42.1	86.1	61.3	0.168
FIB-4
S3-4	0.697 (0.653-0.739)	<0.0001	1.61	58.6	74.7	49.8	80.8	66.5	0.359
S4	0.753 (0.711-0.792)	<0.0001	1.65	70.0	71.5	50.9	84.3	69.6	0.883
GPR
S3-4	0.754 (0.712-0.793)	<0.0001	0.25	72.7	70.0	51.0	85.7	70.2	0.272
S4	0.768 (0.726-0.806)	<0.0001	0.38	69.0	76.9	56.2	85.3	74.0	0.718

AUROC: area under ROC; Se: sensitivity; Sp: specificity; PPV: positive predictive value; NPV: negative predictive value. Compared with PLR.