Neuroprotective Effect of Turmeric Extract in Combination with Its Essential Oil and Enhanced Brain Bioavailability in an Animal Model

Table 1

Impact of turmeric extract and essential oil combination on cognitive performance and biochemical parameters in aluminum chloride-treated mice.

Treatment	Morris water maze	Elevated plus maze		Total proteins (mg/g tissue)	MDA (nM released/mg protein)	GSH (μM/mg tissue)	SOD (U/mg protein)	CAT (U/mg protein)	AchE (nM/mg protein)
	Escape latency (sec)	1st retention (sec)	2nd retention (sec)
Control (vehicle)	^bc	^bc	^bc	^bcd	^b	^bc	bc^d	^b	3^bcd
Untreated control (AlCl3)	^acd	^acd	^acd	^acd	^acd	^acd	^acd	^ad	^acd
AlCl3+TE+EO-25	^ab	^abd	^abd	^ab	^b	^abd	^ab		^abd
AlCl3+TE+EO-50	^b	^bc	^bc	^ab	^b	^bc	^ab	^b	^abc

Values are expressed as the . ^a compared with the control. ^b compared with untreated control (AlCl₃). ^c compared with the AlCl₃+TE+EO-treated group (25 mg/kg); ^d compared with the AlCl₃+TE+EO-treated group (50 mg/kg). comparing second retention with first retention by paired -test. AlCl₃: aluminum chloride; TE+EO: turmeric extract and essential oil combination.