MicroRNA Biomarkers of High-Grade Cervical Intraepithelial Neoplasia in Liquid Biopsy

Figure 1

Expression profiles for highly significant miRNAs. We analyzed nCounter miRNA Expression Assay Panel measurements for 800 miRNAs using -tests to discover differences in expression between samples of subjects with CIN 3 () and those of healthy female subjects (HFS) (). Nine miRNAs displayed statistically significant results (, , and ). Samples are arranged in columns, miRNA expression levels in rows, and both are hierarchically clustered using Euclidean distance with the average linkage of nodes. Red shades indicate increased relative expression; green shades indicate reduced expression; black indicates median expression. The bars above indicate the groups and subgroups used for the analysis. Green indicates the samples from the HFS and the purple subgroup of the CIN 3 group. Black indicates the subgroup hr-HPV positive, and hr-HPV negative is grey.