MicroRNA Biomarkers of High-Grade Cervical Intraepithelial Neoplasia in Liquid Biopsy

Figure 2

Gene expression and correlation between miRNA and mRNA target pairs in CIN 3 patients. (a) The expression of CCND1 in CIN 3 and HFS samples. (b) The expression of EGFR in CIN 3 and HFS samples. (c) The expression of MCM2 in CIN 3 and HFS samples. (d) Pearson’s correlation analysis between has-miR-130a-3p and CCND1 (Pearson’s correlation coefficient, ; ). (e) Pearson’s correlation analysis between has-miR-205-5p and EGFR (Pearson’s correlation coefficient, ; ). (f) Pearson’s correlation analysis between has-miR-4531 and SMAD2 (Pearson’s correlation coefficient, ; ). HFS: healthy female subjects ( =11); CIN 3: cervical intraepithelial neoplasia grade 3 (). value <0.01. Student’s -test was performed to evaluate the gene expression levels between the biological groups.

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