MicroRNA Biomarkers of High-Grade Cervical Intraepithelial Neoplasia in Liquid Biopsy

Table 4

Associations between nine miRNAs differentially expressed and hr-HPV infection (, , and ).

miRNAs		hr-HPV		value
	Regulation	Negative	Positive
		(%)	(%)
miR-205-5p	Upregulated	7 (38.9%)	11 (61.1%)	0.095
	Downregulated	1 (7.7%)	12 (92.3%)
miR-130a-3p	Upregulated	7 (30.4%)	16 (69.6%)	0.642
	Downregulated	1 (12.5%)	7 (87.5%)
miR-3136-5p	Upregulated	4 (30.8%)	9 (69.2%)	0.689
	Downregulated	4 (22.2%)	14 (77.8%)
miR-128-2-5p	Upregulated	6 (35.3%)	11 (64.7%)	0.240
	Downregulated	2 (14.3%)	12 (8.7%)
Let-7f-5p	Upregulated	7 (33.3%)	14 (66.7%)	0.222
	Downregulated	1 (10.0%)	9 (90.0%)
miR-202-3p	Upregulated	7 (31.8%)	15 (68.2%)	0.379
	Downregulated	1 (11.1%)	8 (88.9%)
miR-323a-5p	Upregulated	8 (30.8%)	18 (69.2%)	0.291
	Downregulated	−	5 (100.0%)
miR-381-3p	Upregulated	5 (20.8%)	19 (79.2%)	0.335
	Downregulated	3 (42.9%)	4 (57.1%)
miR-4531	Upregulated	5 (21.7%)	18 (78.3%)	0.393
	Downregulated	3 (37.5%)	5 (62.5%)

Chi-square test was used to identify associations between miRNA expression and hr-HPV infection.