MicroRNA Biomarkers of High-Grade Cervical Intraepithelial Neoplasia in Liquid Biopsy

Table 5

Top 5 pathways related to the best target candidates of the miRNAs differentially expressed between HFS and CIN 3.

Pathway	Genes	value
FoxO signaling pathway	CDKN1A, CDKN1B, PTEN, PIK3CB, STK11, CCND1, EP300, HRAS, TGFBR2, PIK3CA, EGFR, NRAS, MAPK1, SMAD2, SMAD4, STAT3, MDM2, KRAS, ATM
MicroRNAs in cancer	CDKN1A, CDKN1B, PTEN, BRCA1, CCND1, MYC, EP300, HRAS, TP63, PIK3CA, CCNE1, MET, TP53, NOTCH2, NOTCH1, EGFR, NRAS, SOCS1, ABL1, MAPK1, STAT3, APC, BCL2, MDM2, KRAS, ATM
PI3K-Akt signaling pathway	CDKN1A, CDKN1B, FLT4, PTEN, PIK3CB, BRCA1, CCND3, STK11, CCND1, MYC, MYB, HRAS, HSP90AA1, PIK3CA, CCNE1, MET, TP53, EGFR, NRAS, MAPK1, IL2, CDK4, BCL2, MDM2, KRAS
MAPK signaling pathways	RB1, CDKN1A, CDKN1B, CCND3, CCND1, MYC, CHEK2, EP300, CCNE1, TP53, ABL1, SMAD2, SMAD4, CDK4, MDM2, ATM
Intrinsic apoptosis pathways	PIK3CB, HRAS, PIK3CA, DDIT3, TP53, NRAS, MAPK1, JUN, BCL2, FAS, BAX, KRAS, ATM

False discovery rate-corrected (FDR-corrected) value lower than 0.05 was used to identify the molecular cervical cancer pathways.