Review Article

Application of Multiparametric Intraoperative Ultrasound in Glioma Surgery

Table 3

Summary of the applications of navigable ultrasound (NUS) for glioma.

YearFirst author and countryPatient no.GradeGTR (%)Study endpointResult

2019Moiraghi et al. (Italy) [61]31HGG 3161.2To evaluate the impact of real-time conventional neuronavigation combining NUS and preoperative magnetic resonance imaging (MRI) on maximizing EOR in glioma surgery compared to standard conventional neuronavigationThe use of NUS-based real-time imaging modality promoted better EOR and neurological outcomes following the resection of noneloquent high-grade gliomas compared to standard conventional neuronavigation. NUS has proven to be useful in detecting
2019Patil et al. (Indian) [67]125HGG 67
Others 58
ā€”To evaluate the relative utility and benefits of free-hand 2DUS and navigated 3DUS as ultrasound-guided biopsy techniques for supratentorial lesionsDespite the longer operative time and higher postoperative complication rates, NUS was beneficial for biopsies of deep-seated supratentorial lesions, while free-hand 2DUS remained valuable for superficial lesions
2016Rueckriegel et al. (Germany) [68]11HGG 7
LGG 1
Others 3
27.27To assess whether the combined use of navigated ultrasonography integrating FMRIB software library-based probabilistic fiber tracking into neuronavigation was technically feasible and achievable in the preoperative and intraoperative workflowIntegration of probabilistic fiber tracking and navigated ultrasonography into intraoperative neuronavigation facilitated anatomic orientation during glioma resection. Combination with NUS provided a three-dimensional estimation of intraoperative brain shift, thereby improving the reliability of neuronavigation
2014Coburger et al. (Germany) [65]15GBM 1575To evaluate the use of NUS (linear array intraoperative ultrasound) for resection control in glioblastoma surgeryNUS (linear array intraoperative ultrasound) can be used as a safe and precise tool for intracranial image-guided resection control of GBM. NUS showed a significantly higher residual tumor detection rate compared to conventional imaging

RTV: residual tumor volume.