Breakpoints for the Classification of Anti-Candida Compounds in Antifungal Screening

Figure 1

Flowchart of the bibliographic search according to PRISMA guidelines. The first exclusion step targeted studies that did not meet the eligibility criteria, i.e., studies unrelated to the synthesis of organic molecules that were tested according to the CLSI protocol against the reference strains of the genus Candida. After reading the full texts, we excluded studies that did not precisely report the MICs (three studies), studies presenting the results in molarity values (18 studies), and/or studies testing particle improvements in either nanoparticles (five studies) or nanocomposites (one study).