Research Article
Comprehensive Analysis of Common Different Gene Expression Signatures in the Neutrophils of Sepsis
Table 2
The top five up- and downregulated genes in sepsis and their confirmed biological function.
| | Gene symbol | Log FCA1 | Gene title (biological function) |
| | FKBP5 | 1.74 | FK506 binding protein 5 (inflammation and immune system) | | SORT1 | 1.16 | Sortilin 1 (metabolism and inflammation) | | VNN1 | 0.84 | Vanin 1 (metabolic pathway) | | CST7 | 0.76 | Cystatin F (immune system) | | GADD45A | 0.75 | Growth arrest and DNA damage inducible alpha (apoptosis) | | PRR5L | -0.95 | Proline rich protein-5 like (apoptosis) | | SH2B3 | -0.84 | SH2B adaptor protein 3 (inflammation and immune system) | | SULF2 | -0.75 | Sulfatase 2 (metabolism and apoptosis) | | PLEKHO1 | -0.69 | Pleckstrin homology domain containing 01 (inflammation) | | PTPN6 | -0.62 | Protein tyrosine phosphatase nonreceptor type 6 (inflammation) |
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1FCA: average fold change of gene expression value.
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