Research Article
Correlation between TNF-α -308 and +489 Gene Polymorphism and Acute Exacerbation of Chronic Obstructive Pulmonary Diseases
Table 2
Distribution of TNF-α-308 and+489 genotypes in the AECOPD and control groups.
| | Group | No. of samples | Genotypes | Alleles | | GG (%) | GA (%) | AA (%) | G (%) | A (%) |
| | TNF-α-308 | | | | | | | | AECOPD | 198 | 173 (87.37) | 21 (10.61) | 4 (2.02) | 367 (92.68) | 29 (7.32) | | Control | 195 | 186 (95.38) | 9 (4.62) | 0 (0) | 381 (97.69) | 9 (2.31) | | value | | 0.001 | 0.001 | | TNF-α +489 | | | | | | | | AECOPD | 198 | 140 (70.71) | 46 (23.23) | 12 (6.06) | 326 (82.32) | 70 (17.68) | | Control | 195 | 148 (75.90) | 39 (20.00) | 8 (4.10) | 329 (84.36) | 61 (15.64) | | value | | 0.455 | 0.203 |
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