Effect of Statins on Platelet Activation and Function: From Molecular Pathways to Clinical Effects

Table 2

Potential new clinical indications for statins in the primary prevention of cardiovascular disease (adapted from 2019 ESC/EAS Guidelines for the management of dyslipidemias).

Total cardiovascular risk (%)	Untreated LDL level (pretreatment)
	<55 mg/dL	55-70 mg/dL	70-100 mg/dL	100-116 mg/dL	116-190 mg/dL	>190 mg/dL
<1% low risk	Lifestyle interventions	Lifestyle interventions	Lifestyle interventions	Statin might be considered	Statin might be considered	Statin indicated
1-5% moderate risk	Lifestyle interventions	Lifestyle interventions	Statin might be considered	Statin might be considered	Statin might be considered	Statin indicated
5-10% high risk	Lifestyle interventions	Statin might be considered	Statin might be considered	Statin indicated	Statin indicated	Statin indicated
>10% very high risk	Statin might be considered	Statin might be considered	Statin indicated	Statin indicated	Statin indicated	Statin indicated

Adapted from 2019 ESC/EAS Guidelines for the management of dyslipidemias (doi: 10.1093/eurheartj/ehz455). Bold indicates differences from guideline recommendations.