Research Article

[Retracted] A Novel Missense Variant in the Gene PPP2R5D Causes a Rare Neurodevelopmental Disorder with Increased Phenotype

Figure 3

Structural modeling of PPP2R5D protein. The I-TASSER tool predicts the structural changes caused by the p.Trp207Leu variant. (a) Amino acid at position 207 of wild-type PPP2R5D protein interacted with the Glu204 and Gln211 residues through hydrogen bonds which are presented as yellow dashed lines. (b) The formation of hydrogen bonds is predictably altered by the substitution of tryptophan by leucine at position 207.
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