Bioinformatics Analysis: The Regulatory Network of hsa_circ_0007843 and hsa_circ_0007331 in Colon Cancer
Table 1
Colon cancer-associated miRNAs.
miRNA name
PMID
Description
Expression
hsa-miR-145
22766504
miR-145 regulates PAK4 via the MAPK pathway and exhibits an antitumor effect in human colon cells.
Downregulation
hsa-miR-330
22132977
Expression of miR-330 in various colon cancer cell lines varied fivefold between samples and correlated with in vitro gemcitabine resistance.
Downregulation
hsa-miR-326
22043014
The development of colonic inflammation in IL-10(-/-) mice was accompanied by upregulation in the expression of 10 miRNAs (miR-19a, miR-21, miR-31, etc.).
Upregulation
hsa-miR-766
30127618
Verified by qRT-PCR, the expression of hsa-miR-766 was upregulated in colon cancer cells.
Upregulation
hsa-miR-21
21279518
PDCD4 nuclear loss inversely correlates with miR-21 levels in colon carcinogenesis.
