[Retracted] Protease-Activated Receptor 1 Contributes to Microcirculation Failure and Tubular Damage in Renal Ischemia-Reperfusion Injury in Mice

Figure 4

PAR-1 inhibition on the proliferation of tubular cells. The proliferation ability of tubular cells was evaluated by Ki-67 IHC staining in vivo and in vitro. Treatment with Q94 increased the number of Ki-67-positive cells compared to that in mouse kidneys (a, b). , vs. IR+vehicle. . The proliferation ability of tubular cells in vitro was evaluated by WST-1 assay, which showed that Q94 abolished the inhibition of HK2 cell proliferation incubated with thrombin at 72 h (c) (). , vs. thrombin+vehicle. NS.: not significant. Increased activity of caspase-3 was attenuated by Q94 () (d). . , vs. thrombin+vehicle.

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