Research Article
Predicting Ovarian/Breast Cancer Pathogenic Risks of Human BRCA1 Gene Variants of Unknown Significance
Table 3
Predictive pathogenic risks for 7 VUSs of BRCA1 identified from our sequencing data.
| | ID | Variation | (Original) clinical significance | Predictive pathogenic risk |
| | 1 | c.1255G>C | Unknown | Pathogenic | | 2 | c.824G>A | Unknown | Benign | | 3 | c.3448C>T | Unknown | Benign | | 4a | c.1348A>T | Unknown | Pathogenic | | 5 | c.2566T>C | Likely benign | Benign | | 6 | c.3748G>A | Likely benign | Benign | | 7 | c.571G>A | Likely benign | Benign |
|
|
aExcept this variant, the rest of the variants can be found in the ClinVar database.
|
