Predicting Ovarian/Breast Cancer Pathogenic Risks of Human BRCA1 Gene Variants of Unknown Significance

Table 4

Overview of predictive results for 6321 BRCA1 VUS pathogenic risks.

Class	Clinical significance (ClinVar database)	Variant amount	Number of predictive pathogenic variants (%)	Number of predictive benign variants (%)
1	Likely benign	937	227 (24.22%)	710 (75.78%)
2	Likely pathogenic	82	25 (30.49%)	57 (69.51%)
3	Not provided	2797	621 (22.20%)	2176 (77.80%)
4	Uncertain significance	2235	644 (28.81%)	1591 (71.19%)
5	Conflicting interpretations of pathogenicity	264	74 (28.03%)	190 (71.97%)
6	Total	6315	1591 (25.19%)	4724 (74.81%)